{"id":16103,"date":"2023-11-01T14:38:28","date_gmt":"2023-11-01T07:38:28","guid":{"rendered":"http:\/\/kenh69.info\/?p=16103"},"modified":"2023-11-01T14:38:43","modified_gmt":"2023-11-01T07:38:43","slug":"16103-2","status":"publish","type":"post","link":"http:\/\/kenh69.info\/?p=16103","title":{"rendered":"Thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa kh\u1ecfi ung th\u01b0 c\u1ee7a M\u1ef8 ho\u1ea1t \u0111\u1ed9ng th\u1ebf n\u00e0o"},"content":{"rendered":"<p>Dostarlimab l\u00e0 lo\u1ea1i thu\u1ed1c ng\u0103n ch\u1eb7n \u1ea3nh h\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch, khi\u1ebfn c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u00ecm v\u00e0 ti\u00eau di\u1ec7t kh\u1ed1i u hi\u1ec7u qu\u1ea3.<\/p>\n<p>C\u00e1c nh\u00e0 khoa h\u1ecdc h\u00f4m 8\/6 t\u1ecf ra ph\u1ea5n kh\u00edch tr\u01b0\u1edbc th\u00f4ng tin v\u1ec1 lo\u1ea1i\u00a0thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa kh\u1ecfi ho\u00e0n to\u00e0n ung th\u01b0 tr\u1ef1c tr\u00e0ng. Thu\u1ed1c t\u00ean dostarlimab, \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 sau m\u1ed9t th\u1eed nghi\u1ec7m nh\u1ecf \u1edf M\u1ef9, trong \u0111\u00f3 12 b\u1ec7nh nh\u00e2n ung th\u01b0 tr\u1ef1c tr\u00e0ng \u0111\u1ec1u thuy\u00ean gi\u1ea3m 100% sau khi s\u1eed d\u1ee5ng thu\u1ed1c trong kho\u1ea3ng 6 th\u00e1ng.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/tapchivietkieu.info\/wp-content\/uploads\/2cf64d32edb63b30821cc32fc1e63b17.jpg\" alt=\"Y\u1ebfu t\u1ed1 quan tr\u1ecdng nh\u1ea5t trong vi\u1ec7c ph\u00f2ng ch\u1ed1ng b\u1ec7nh ung th\u01b0 ph\u1ed5i l\u00e0 kh\u00f4ng h\u00fat thu\u1ed1c l\u00e1\" width=\"658\" height=\"407\" data-height=\"407\" data-width=\"658\" \/><\/p>\n<p>H\u1ecd th\u1eed cho b\u1ec7nh nh\u00e2n d\u00f9ng thu\u1ed1c dostarlimab, ti\u00eam ba tu\u1ea7n m\u1ed9t l\u1ea7n trong v\u00f2ng 6 th\u00e1ng, c\u00f3 gi\u00e1 kho\u1ea3ng 11.000 USD m\u1ed7i li\u1ec1u. Thu\u1ed1c t\u00ecm ra t\u1ebf b\u00e0o ung th\u01b0, \u201cph\u01a1i b\u00e0y\u201d ch\u00fang \u0111\u1ec3 h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch x\u00e1c \u0111\u1ecbnh v\u00e0 ti\u00eau di\u1ec7t.<\/p>\n<p>T\u1ef7 l\u1ec7 thuy\u00ean gi\u1ea3m n\u00e0y l\u00e0 \u0111i\u1ec1u ch\u01b0a t\u1eebng c\u00f3 ti\u1ec1n l\u1ec7, c\u0169ng l\u00e0 nguy\u00ean nh\u00e2n khi\u1ebfn m\u1ed9t s\u1ed1 chuy\u00ean gia l\u1ea1c quan \u0111\u1ebfn v\u1eady. Tuy nhi\u00ean, c\u00e1c chuy\u00ean gia kh\u00e1c l\u01b0u \u00fd \u0111\u00e2y ch\u1ec9 l\u00e0 th\u1eed nghi\u1ec7m nh\u1ecf, c\u1ea7n nghi\u00ean c\u1ee9u s\u00e2u r\u1ed9ng h\u01a1n.<\/p>\n<p>Dostarlimab \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u1edf M\u1ef9 v\u00e0 ch\u00e2u \u00c2u v\u00e0o th\u00e1ng 4\/2021. \u0110\u00e2y l\u00e0 lo\u1ea1i thu\u1ed1c mi\u1ec5n d\u1ecbch s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung, t\u00e1c \u0111\u1ed9ng v\u00e0o ni\u00eam m\u1ea1c t\u1eed cung, c\u00f3 hi\u1ec7u qu\u1ea3 r\u1ea5t cao. N\u0103m 2022, c\u00e1c nh\u00e0 khoa h\u1ecdc l\u1ea7n \u0111\u1ea7u ti\u00ean th\u1eed nghi\u1ec7m thu\u1ed1c tr\u00ean kh\u1ed1i u tr\u1ef1c tr\u00e0ng.<\/p>\n<p><strong>C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng<\/strong><\/p>\n<p>Dostarlimab l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch. Thu\u1ed1c kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng tr\u1ef1c ti\u1ebfp v\u00e0o ch\u00ednh kh\u1ed1i u ung th\u01b0, m\u00e0 th\u00fac \u0111\u1ea9y h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n th\u1ef1c hi\u1ec7n \u0111i\u1ec1u n\u00e0y.<\/p>\n<p>Th\u00f4ng th\u01b0\u1eddng, t\u1ebf b\u00e0o T (t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch) c\u00f3 nhi\u1ec7m v\u1ee5 t\u00ecm ki\u1ebfm v\u00e0 ki\u1ec3m so\u00e1t c\u00e1c t\u1ebf b\u00e0o nhi\u1ec5m b\u1ec7nh l\u1ea1. Ch\u00fang ch\u1ee9a hai lo\u1ea1i protein: lo\u1ea1i th\u1ee9 nh\u1ea5t (lo\u1ea1i m\u1ed9t) gi\u00fap k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch, lo\u1ea1i hai h\u1ea1n ch\u1ebf kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch. \u0110\u00e2y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 nh\u1eefng protein \u0111i\u1ec3m ki\u1ec3m so\u00e1t.<\/p>\n<p>Protein \u0111i\u1ec3m ki\u1ec3m so\u00e1t lo\u1ea1i m\u1ed9t k\u00edch ho\u1ea1t t\u1ebf b\u00e0o T, nh\u01b0ng n\u1ebfu t\u1ebf b\u00e0o T l\u00e0m vi\u1ec7c qu\u00e1 l\u00e2u, n\u00f3 b\u1eaft \u0111\u1ea7u ph\u00e1 h\u1ee7y c\u00e1c m\u00f4 kh\u1ecfe m\u1ea1nh. L\u00fac n\u00e0y, protein lo\u1ea1i hai b\u00e1o hi\u1ec7u t\u1ebf b\u00e0o T ng\u1eebng ho\u1ea1t \u0111\u1ed9ng.<\/p>\n<p>M\u1ed9t s\u1ed1 t\u1ebf b\u00e0o ung th\u01b0 t\u1ea1o ra l\u01b0\u1ee3ng protein lo\u1ea1i hai cao. Ch\u00fang c\u00f3 th\u1ec3 b\u1ea5t ho\u1ea1t t\u1ebf b\u00e0o T tr\u01b0\u1edbc khi kh\u1ed1i u bi\u1ebfn m\u1ea5t. N\u00f3i c\u00e1ch kh\u00e1c, t\u1ebf b\u00e0o ung th\u01b0 khi\u1ebfn h\u1ec7 mi\u1ec5n d\u1ecbch \u1edf ng\u01b0\u1eddi b\u1ec7nh \u0111\u00ecnh tr\u1ec7. C\u00e1c t\u1ebf b\u00e0o T kh\u00f4ng c\u00f2n kh\u1ea3 n\u0103ng nh\u1eadn bi\u1ebft v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 n\u1eefa.<\/p>\n<p>Do \u0111\u00f3, thu\u1ed1c dostarlimab ng\u0103n ch\u1eb7n c\u00e1c protein \u0111i\u1ec3m ki\u1ec3m so\u00e1t lo\u1ea1i hai, t\u1ee9c l\u00e0 ng\u0103n ch\u1eb7n \u1ea3nh h\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch. \u0110i\u1ec1u n\u00e0y khi\u1ebfn h\u1ec7 mi\u1ec5n d\u1ecbch ho\u1ea1t \u0111\u1ed9ng tr\u1edf l\u1ea1i, c\u00e1c t\u1ebf b\u00e0o T c\u00f3 th\u1ec3 t\u00ecm th\u1ea5y v\u00e0 t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n<p>Trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, kh\u00f4ng b\u1ec7nh nh\u00e2n n\u00e0o c\u00f3 bi\u1ebfn ch\u1ee9ng \u0111\u00e1ng k\u1ec3. Trung b\u00ecnh, m\u1ed9t ph\u1ea7n 5 b\u1ec7nh nh\u00e2n c\u00f3 ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i v\u1edbi thu\u1ed1c, nh\u01b0ng \u0111\u1ec1u d\u1ec5 d\u00e0ng ki\u1ec3m so\u00e1t v\u00e0 \u0111i\u1ec1u tr\u1ecb. 3% \u0111\u1ebfn 5% b\u1ec7nh nh\u00e2n c\u00f3 bi\u1ebfn ch\u1ee9ng n\u1eb7ng h\u01a1n, d\u1eabn \u0111\u1ebfn y\u1ebfu c\u01a1, kh\u00f3 nhai v\u00e0 nu\u1ed1t.<\/p>\n<figure data-size=\"true\"><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/tapchivietkieu.info\/wp-content\/uploads\/e3be674c5896ad31e99c419c2cfe2ed2.jpg\" alt=\"Thu\u1ed1c Dostarlimab \u0111i\u1ec1u tr\u1ecb ung th\u01b0. \u1ea2nh: GSK\" width=\"678\" height=\"504\" data-src=\"https:\/\/i1-suckhoe.vnecdn.net\/2022\/06\/12\/thuo-c-1655003740-8920-1655003821.png?w=680&amp;h=0&amp;q=100&amp;dpr=1&amp;fit=crop&amp;s=bIluIKudVRRMg72RklJKlg\" data-ll-status=\"loaded\" data-height=\"504\" data-width=\"678\" \/><\/figure>\n<p><strong>Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c t\u1ea5t c\u1ea3 b\u1ec7nh ung th\u01b0 kh\u00f4ng?<\/strong><\/p>\n<p>\u0110\u00e2y l\u00e0 c\u00e2u h\u1ecfi l\u1edbn nh\u1ea5t \u0111\u1ed1i v\u1edbi c\u00e1c nh\u00e0 khoa h\u1ecdc. Theo ti\u1ebfn s\u0129 Aju Mathew, chuy\u00ean gia t\u1ea1i Trung t\u00e2m Ung th\u01b0 Ernakulam, c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf nh\u01b0 dostarlimab ch\u1ec9 ph\u00f9 h\u1ee3p v\u1edbi b\u1ec7nh nh\u00e2n b\u1ecb suy gi\u1ea3m ch\u1ee9c n\u0103ng h\u1ec7 th\u1ed1ng s\u1eeda l\u1ed7i gh\u00e9p c\u1eb7p DNA (MMR).<\/p>\n<p>Nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y c\u00f3 m\u1ed9t s\u1ed1 \u0111\u1ed9t bi\u1ebfn gene nh\u1ea5t \u0111\u1ecbnh, khi\u1ebfn h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa g\u1eb7p sai l\u1ea7m khi gh\u00e9p c\u1eb7p DNA trong t\u1ebf b\u00e0o. C\u00e1c t\u1ebf b\u00e0o kh\u00f4ng \u0111\u01b0\u1ee3c s\u1eeda l\u1ed7i th\u01b0\u1eddng c\u00f3 nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn gene, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ung th\u01b0.<\/p>\n<p>Tuy nhi\u00ean, t\u00ecnh tr\u1ea1ng tr\u00ean ch\u1ec9 x\u1ea3y ra \u1edf d\u01b0\u1edbi 10% b\u1ec7nh nh\u00e2n ung th\u01b0 ru\u1ed9t k\u1ebft. V\u00ec v\u1eady, thu\u1ed1c ch\u01b0a ch\u1eafc hi\u1ec7u qu\u1ea3 tr\u00ean nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.<\/p>\n<p>MMR ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf ng\u01b0\u1eddi m\u1eafc ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, c\u00e1c lo\u1ea1i ung th\u01b0 \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 ung th\u01b0 n\u1ed9i m\u1ea1c t\u1eed cung. M\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa, tuy\u1ebfn gi\u00e1p, tuy\u1ebfn ti\u1ec1n li\u1ec7t v\u00e0 b\u00e0ng quang c\u0169ng g\u1eb7p t\u00ecnh tr\u1ea1ng n\u00e0y.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/tapchivietkieu.info\/wp-content\/uploads\/5c801a48019d33e058744627ad6f9de8.jpg\" alt=\"Thu\u1ed1c ch\u1eefa kh\u1ecfi ung th\u01b0 cho 100% b\u1ec7nh nh\u00e2n th\u1eed nghi\u1ec7m ho\u1ea1t \u0111\u1ed9ng th\u1ebf n\u00e0o?\" width=\"698\" height=\"436\" data-height=\"436\" data-width=\"698\" \/><\/p>\n<p><strong>Thu\u1ed1c c\u00f3 ph\u1ea3i \u201cth\u1ea7n d\u01b0\u1ee3c\u201d ch\u1eefa ung th\u01b0?<\/strong><\/p>\n<p>Trong nh\u1eefng ng\u00e0y qua, ti\u1ebfn s\u0129 Mathew nh\u1eadn \u0111\u01b0\u1ee3c v\u00f4 s\u1ed1 c\u00e2u h\u1ecfi li\u1ec7u \u0111\u00e2y c\u00f3 ph\u1ea3i ph\u01b0\u01a1ng ph\u00e1p k\u1ef3 di\u1ec7u, ch\u1eefa kh\u1ecfi ho\u00e0n to\u00e0n b\u1ec7nh ung th\u01b0 hay kh\u00f4ng. \u00d4ng th\u1eeba nh\u1eadn dostarlimab l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u1ea7y h\u1ee9a h\u1eb9n, song l\u01b0u \u00fd c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u1ec1u r\u1ea5t nh\u1ecf, ch\u1ec9 c\u00f3 k\u1ebft qu\u1ea3 tr\u00ean b\u1ec7nh nh\u00e2n m\u1eafc m\u1ed9t lo\u1ea1i ung th\u01b0 c\u1ee5 th\u1ec3.<\/p>\n<p>Ti\u1ebfn s\u0129 Nitesh Rohatgi, gi\u00e1m \u0111\u1ed1c c\u1ea5p cao, khoa ung th\u01b0, Vi\u1ec7n nghi\u00ean c\u1ee9u Fortis Memorial, cho r\u1eb1ng dostarlimab n\u00ean \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh c\u00f9ng v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c kh\u00e1c, thay v\u00ec d\u00f9ng \u0111\u1ed9c l\u1eadp.<\/p>\n<p>Theo ti\u1ebfn s\u0129 CS Pramesh, gi\u00e1m \u0111\u1ed1c Trung t\u00e2m T\u01b0\u1edfng ni\u1ec7m Tata \u1edf Mumbai, vi\u1ec7c g\u1ecdi dostarlimab v\u1edbi t\u00ean \u201cth\u1ea7n d\u01b0\u1ee3c ch\u1eefa ung th\u01b0, c\u00f3 th\u1ec3 t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb to\u00e0n c\u1ea7u\u201d l\u00e0 qu\u00e1 s\u1edbm v\u00e0 vi\u1ec3n v\u00f4ng.<\/p>\n<p>\u201cD\u00f9 k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u \u0111\u00e1ng ch\u00fa \u00fd, ch\u00fang ta c\u1ea7n \u0111i\u1ec1u tr\u1ecb, theo d\u00f5i s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n l\u1edbn, th\u1ef1c hi\u1ec7n th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean l\u1edbn h\u01a1n m\u1edbi c\u00f3 th\u1ec3 k\u1ebft lu\u1eadn lo\u1ea1i thu\u1ed1c n\u00e0y gi\u00fap thay \u0111\u1ed5i cu\u1ed9c ch\u01a1i\u201d, \u00f4ng n\u00f3i.<\/p>\n<p>Theo ti\u1ebfn s\u0129 Rohatgi, v\u1edbi k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u m\u1edbi, c\u1ed9ng \u0111\u1ed3ng th\u1eddi \u0111i\u1ec3m n\u00e0y ch\u1ec9 n\u00ean mong \u0111\u1ee3i m\u1ed9t li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ch\u1eefa ung th\u01b0 ru\u1ed9t k\u1ebft, c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng tr\u01b0\u1edbc khi ph\u1eabu thu\u1eadt.<\/p>\n<p>Ti\u1ebfp \u0111\u1ebfn, c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ea7n th\u1ef1c hi\u1ec7n ph\u00e2n t\u00edch b\u1ed9 gen, hi\u1ec3u r\u00f5 \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc c\u1ee7a b\u1ec7nh ung th\u01b0 v\u00e0 t\u00ecm ra ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u1ee5 th\u1ec3 cho b\u1ec7nh nh\u00e2n c\u1ee5 th\u1ec3, ti\u1ebfn s\u0129 Sewanti Limaye, gi\u00e1m \u0111\u1ed1c khoa ung th\u01b0 t\u1ea1i b\u1ec7nh vi\u1ec7n Sir HN Reliance Foundation, nh\u1eadn \u0111\u1ecbnh.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dostarlimab l\u00e0 lo\u1ea1i thu\u1ed1c ng\u0103n ch\u1eb7n \u1ea3nh h\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch, khi\u1ebfn c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u00ecm v\u00e0 ti\u00eau di\u1ec7t kh\u1ed1i u hi\u1ec7u qu\u1ea3. C\u00e1c nh\u00e0 khoa h\u1ecdc h\u00f4m 8\/6 t\u1ecf ra ph\u1ea5n kh\u00edch tr\u01b0\u1edbc th\u00f4ng tin v\u1ec1 lo\u1ea1i\u00a0thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa kh\u1ecfi ho\u00e0n to\u00e0n ung th\u01b0 tr\u1ef1c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16104,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/kenh69.info\/?p=16103\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa kh\u1ecfi ung th\u01b0 c\u1ee7a M\u1ef8 ho\u1ea1t \u0111\u1ed9ng th\u1ebf n\u00e0o\" \/>\n<meta property=\"og:description\" content=\"Dostarlimab l\u00e0 lo\u1ea1i thu\u1ed1c ng\u0103n ch\u1eb7n \u1ea3nh h\u01b0\u1edfng c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch, khi\u1ebfn c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u00ecm v\u00e0 ti\u00eau di\u1ec7t kh\u1ed1i u hi\u1ec7u qu\u1ea3. 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